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Professor Thomas Blundell: Science, Society and Spinouts | Bio21 Institute | onsdag, 25. september 2019

Science, Society and Spinouts: From Genomes and Structural Biology to Drug Discovery

Professor Thomas Blundell, FRS, FMedSci
Department of Biochemistry
University of Cambridge
Tom Blundell maintains an active laboratory as Director of Research and Professor Emeritus in the Department of Biochemistry, University of Cambridge, where he was previously Sir William Dunn Professor and Head of Department between 1996 and 2009, and Chair of School of Biological Sciences between 2003 and 2009. He is a Fellow of the Royal Society, member of the European Molecular Biology Organisation (EMBO), fellow of the Academy of Medical Sciences (UK) amongst other prestigious posts.
He has made many important contributions over his distinguished career as a structural biologist in understanding polypeptide hormones, growth factors, receptor activation, signal transduction, and DNA repair. He has produced many widely used software packages for protein modelling and design and for predicting effects of mutations and to understand cancer & drug resistance. He has published ~630 research papers, including ~40 in Nature and Science, and has an H-factor of 114.
Tom has developed new approaches to structure-guided and fragment-based drug discovery. In 1999 he co-founded Astex Therapeutics, an oncology company that has eight drugs in clinical trials and that was sold in 2013 for $886 million. In parallel in the University of Cambridge he has developed structure-guided fragment-based approaches to drug discovery for difficult targets involving multiprotein systems and protein-protein interactions. He has also been targeting Mycobacterium tuberculosis proteins as part of the Gates HIT-TB and EU-FP7 MM4TB consortia, including structural and biochemical studies of resistance mutations to first-line drugs.
Tom was a member of PM Margaret Thatcher’s Advisory Council on Science & Technology (1988-1990), Founding CEO of Biotechnology and Biological Sciences Research Council, 1991-1996 (Chair 2009-2015), Chairman, Royal Commission on Environment (1998-2005), Deputy Chair of Institute of Cancer Research 2008-2015 and President of UK Science Council, 2011- 2016.